There is an increasing need for innovative drug and prophylaxis discovery against malaria. The aim of the present study was to test\nin vivo antiplasmodial activity of Croton macrostachyus H. (Euphorbiaceae) stem bark extracts from Kenyan folkloric medicine.\nInbred Balb/c mice were inoculated with erythrocytes parasitized with Plasmodium berghei (ANKA). Different doses (500, 250,\nand 100 mg/kg) of C. macrostachyus ethyl acetate, methanol, aqueous, and isobutanol extracts were administrated either after\ninoculation (Petersâ?? 4-day suppressive test) or before inoculation (chemoprotective test) of the parasitized erythrocytes. All the\nextracts showed significant suppression of parasitemia compared to control............
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